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The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer
Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567227/ https://www.ncbi.nlm.nih.gov/pubmed/26379447 http://dx.doi.org/10.2147/BCTT.S71163 |
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author | Voutsadakis, Ioannis A |
author_facet | Voutsadakis, Ioannis A |
author_sort | Voutsadakis, Ioannis A |
collection | PubMed |
description | Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeutic decisions based on their biology and the expected benefit from various interventions. Despite this progress, a significant percentage of patients die from their disease and further improvements are needed. The cancer stem cell theory and the epithelial–mesenchymal transition are two comparatively novel concepts that have been introduced in the area of cancer research and are actively investigated. Both processes have their physiologic roots in normal development and common mediators have begun to surface. This review discusses the associations of these networks as a prognostic framework in breast cancer. |
format | Online Article Text |
id | pubmed-4567227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45672272015-09-14 The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer Voutsadakis, Ioannis A Breast Cancer (Dove Med Press) Review Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeutic decisions based on their biology and the expected benefit from various interventions. Despite this progress, a significant percentage of patients die from their disease and further improvements are needed. The cancer stem cell theory and the epithelial–mesenchymal transition are two comparatively novel concepts that have been introduced in the area of cancer research and are actively investigated. Both processes have their physiologic roots in normal development and common mediators have begun to surface. This review discusses the associations of these networks as a prognostic framework in breast cancer. Dove Medical Press 2015-09-07 /pmc/articles/PMC4567227/ /pubmed/26379447 http://dx.doi.org/10.2147/BCTT.S71163 Text en © 2015 Voutsadakis. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Voutsadakis, Ioannis A The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title | The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title_full | The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title_fullStr | The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title_full_unstemmed | The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title_short | The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
title_sort | network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567227/ https://www.ncbi.nlm.nih.gov/pubmed/26379447 http://dx.doi.org/10.2147/BCTT.S71163 |
work_keys_str_mv | AT voutsadakisioannisa thenetworkofpluripotencyepithelialmesenchymaltransitionandprognosisofbreastcancer AT voutsadakisioannisa networkofpluripotencyepithelialmesenchymaltransitionandprognosisofbreastcancer |