Cargando…
To Hit or Not to Hit, That Is the Question – Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins
Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore sought after. To this end, we subjected the gene products of predicted perturbativ...
Autores principales: | Sarkar, Aurijit, Brenk, Ruth |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567284/ https://www.ncbi.nlm.nih.gov/pubmed/26360059 http://dx.doi.org/10.1371/journal.pone.0137279 |
Ejemplares similares
-
Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations
por: Lee, Ji Young, et al.
Publicado: (2019) -
An Experimental Toolbox for Structure‐Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
por: Espeland, Ludvik Olai, et al.
Publicado: (2021) -
A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins
por: Sarkar, Aurijit, et al.
Publicado: (2015) -
The two-hit theory hits 50
por: Chernoff, Jonathan
Publicado: (2021) -
DrugPred_RNA—A Tool for Structure-Based Druggability
Predictions for RNA Binding Sites
por: Rekand, Illimar Hugo, et al.
Publicado: (2021)