Structure Based Thermostability Prediction Models for Protein Single Point Mutations with Machine Learning Tools

Thermostability issue of protein point mutations is a common occurrence in protein engineering. An application which predicts the thermostability of mutants can be helpful for guiding decision making process in protein design via mutagenesis. An in silico point mutation scanning method is frequently...

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Detalles Bibliográficos
Autores principales: Jia, Lei, Yarlagadda, Ramya, Reed, Charles C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567301/
https://www.ncbi.nlm.nih.gov/pubmed/26361227
http://dx.doi.org/10.1371/journal.pone.0138022

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