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Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis

OBJECTIVES: Although CT scanners generally allow dynamic acquisition of thin slices (1 mm), thick slice (≥5 mm) reconstruction is commonly used for stroke imaging to reduce data, processing time, and noise level. Thin slice CT perfusion (CTP) reconstruction may suffer less from partial volume effect...

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Autores principales: Bennink, Edwin, Oosterbroek, Jaap, Horsch, Alexander D., Dankbaar, Jan Willem, Velthuis, Birgitta K., Viergever, Max A., de Jong, Hugo W. A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567308/
https://www.ncbi.nlm.nih.gov/pubmed/26361391
http://dx.doi.org/10.1371/journal.pone.0137766
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author Bennink, Edwin
Oosterbroek, Jaap
Horsch, Alexander D.
Dankbaar, Jan Willem
Velthuis, Birgitta K.
Viergever, Max A.
de Jong, Hugo W. A. M.
author_facet Bennink, Edwin
Oosterbroek, Jaap
Horsch, Alexander D.
Dankbaar, Jan Willem
Velthuis, Birgitta K.
Viergever, Max A.
de Jong, Hugo W. A. M.
author_sort Bennink, Edwin
collection PubMed
description OBJECTIVES: Although CT scanners generally allow dynamic acquisition of thin slices (1 mm), thick slice (≥5 mm) reconstruction is commonly used for stroke imaging to reduce data, processing time, and noise level. Thin slice CT perfusion (CTP) reconstruction may suffer less from partial volume effects, and thus yield more accurate quantitative results with increased resolution. Before thin slice protocols are to be introduced clinically, it needs to be ensured that this does not affect overall CTP constancy. We studied the influence of thin slice reconstruction on average perfusion values by comparing it with standard thick slice reconstruction. MATERIALS AND METHODS: From 50 patient studies, absolute and relative hemisphere averaged estimates of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and permeability-surface area product (PS) were analyzed using 0.8, 2.4, 4.8, and 9.6 mm slice reconstructions. Specifically, the influence of Gaussian and bilateral filtering, the arterial input function (AIF), and motion correction on the perfusion values was investigated. RESULTS: Bilateral filtering gave noise levels comparable to isotropic Gaussian filtering, with less partial volume effects. Absolute CBF, CBV and PS were 22%, 14% and 46% lower with 0.8 mm than with 4.8 mm slices. If the AIF and motion correction were based on thin slices prior to reconstruction of thicker slices, these differences reduced to 3%, 4% and 3%. The effect of slice thickness on relative values was very small. CONCLUSIONS: This study shows that thin slice reconstruction for CTP with unaltered acquisition protocol gives relative perfusion values without clinically relevant bias. It does however affect absolute perfusion values, of which CBF and CBV are most sensitive. Partial volume effects in large arteries and veins lead to overestimation of these values. The effects of reconstruction slice thickness should be taken into account when absolute perfusion values are used for clinical decision making.
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spelling pubmed-45673082015-09-18 Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis Bennink, Edwin Oosterbroek, Jaap Horsch, Alexander D. Dankbaar, Jan Willem Velthuis, Birgitta K. Viergever, Max A. de Jong, Hugo W. A. M. PLoS One Research Article OBJECTIVES: Although CT scanners generally allow dynamic acquisition of thin slices (1 mm), thick slice (≥5 mm) reconstruction is commonly used for stroke imaging to reduce data, processing time, and noise level. Thin slice CT perfusion (CTP) reconstruction may suffer less from partial volume effects, and thus yield more accurate quantitative results with increased resolution. Before thin slice protocols are to be introduced clinically, it needs to be ensured that this does not affect overall CTP constancy. We studied the influence of thin slice reconstruction on average perfusion values by comparing it with standard thick slice reconstruction. MATERIALS AND METHODS: From 50 patient studies, absolute and relative hemisphere averaged estimates of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and permeability-surface area product (PS) were analyzed using 0.8, 2.4, 4.8, and 9.6 mm slice reconstructions. Specifically, the influence of Gaussian and bilateral filtering, the arterial input function (AIF), and motion correction on the perfusion values was investigated. RESULTS: Bilateral filtering gave noise levels comparable to isotropic Gaussian filtering, with less partial volume effects. Absolute CBF, CBV and PS were 22%, 14% and 46% lower with 0.8 mm than with 4.8 mm slices. If the AIF and motion correction were based on thin slices prior to reconstruction of thicker slices, these differences reduced to 3%, 4% and 3%. The effect of slice thickness on relative values was very small. CONCLUSIONS: This study shows that thin slice reconstruction for CTP with unaltered acquisition protocol gives relative perfusion values without clinically relevant bias. It does however affect absolute perfusion values, of which CBF and CBV are most sensitive. Partial volume effects in large arteries and veins lead to overestimation of these values. The effects of reconstruction slice thickness should be taken into account when absolute perfusion values are used for clinical decision making. Public Library of Science 2015-09-11 /pmc/articles/PMC4567308/ /pubmed/26361391 http://dx.doi.org/10.1371/journal.pone.0137766 Text en © 2015 Bennink et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bennink, Edwin
Oosterbroek, Jaap
Horsch, Alexander D.
Dankbaar, Jan Willem
Velthuis, Birgitta K.
Viergever, Max A.
de Jong, Hugo W. A. M.
Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title_full Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title_fullStr Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title_full_unstemmed Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title_short Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis
title_sort influence of thin slice reconstruction on ct brain perfusion analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567308/
https://www.ncbi.nlm.nih.gov/pubmed/26361391
http://dx.doi.org/10.1371/journal.pone.0137766
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