Cargando…

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

OBJECTIVE: Metformin is used to treat type 2 diabetes. We sought to determine whether metformin reduces inflammation, by regulating p-signal transducer and activator of transcription 3 (STAT3) expression and T-helper 17 (Th17) cell proliferation, in a mouse model of inflammatory bowel disease (IBD)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seon-Yeong, Lee, Seung Hoon, Yang, Eun-Ji, Kim, Eun-Kyung, Kim, Jae-Kyung, Shin, Dong-Yun, Cho, Mi-La
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567351/ https://www.ncbi.nlm.nih.gov/pubmed/26360050 http://dx.doi.org/10.1371/journal.pone.0135858

Ejemplares similares

Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis
por: Son, Hye-Jin, et al.
Publicado: (2014)

PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
por: Lee, Seung Hoon, et al.
Publicado: (2016)

GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation
por: Park, Min-Jung, et al.
Publicado: (2016)

Corrigendum: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
por: Lee, Seung Hoon, et al.
Publicado: (2017)

Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
por: Park, Mi Kyung, et al.
Publicado: (2016)

Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17/Treg Balance, and Osteoclastogenesis in Mice and Human
por: Jhun, JooYeon, et al.
Publicado: (2014)

Erratum to: Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
por: Park, Mi-Kyung, et al.
Publicado: (2016)

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control
por: Yang, Eun-Ji, et al.
Publicado: (2014)

Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis
por: Min, Hong-Ki, et al.
Publicado: (2016)

GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance
por: Jhun, JooYeon, et al.
Publicado: (2021)

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
por: Moon, Jeonghyeon, et al.
Publicado: (2021)

Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
por: Moon, Jeonghyeon, et al.
Publicado: (2021)

Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation
por: Jang, Sung Woong, et al.
Publicado: (2017)

Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
por: Moon, Jeonghyeon, et al.
Publicado: (2020)

The Balance of Th17 versus Treg Cells in Autoimmunity
por: Lee, Gap Ryol
Publicado: (2018)

Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg
por: Lee, Seon-yeong, et al.
Publicado: (2019)

The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease
por: Yan, Jun-bin, et al.
Publicado: (2020)

Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis
por: Min, Hong-Ki, et al.
Publicado: (2019)

N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis
por: Kim, Ji Young, et al.
Publicado: (2018)

Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease
por: Xie, Fengjiao, et al.
Publicado: (2022)

Ssu72 attenuates autoimmune arthritis via targeting of STAT3 signaling and Th17 activation
por: Lee, Seung Hoon, et al.
Publicado: (2017)

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21
por: Kim, Eun Kyung, et al.
Publicado: (2016)

Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
por: Kim, Eun-Kyung, et al.
Publicado: (2018)

The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases
por: Zhang, Siwen, et al.
Publicado: (2021)

Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection
por: Li, Jing, et al.
Publicado: (2016)

Interferon Gamma Suppresses Collagen-Induced Arthritis by Regulation of Th17 through the Induction of Indoleamine-2,3-Deoxygenase
por: Lee, Jaeseon, et al.
Publicado: (2013)

Moxibustion and Acupuncture Ameliorate Crohn's Disease by Regulating the Balance between Th17 and Treg Cells in the Intestinal Mucosa
por: Zhao, Chen, et al.
Publicado: (2015)

T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance
por: Yang, Xiaoshan, et al.
Publicado: (2021)

Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice
por: Wei, Chaochao, et al.
Publicado: (2021)

Combination Treatment With Metformin and Tacrolimus Improves Systemic Immune Cellular Homeostasis by Modulating Treg and Th17 Imbalance
por: Lee, Soon Kyu, et al.
Publicado: (2021)

In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
por: Moon, Su-Jin, et al.
Publicado: (2013)

A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance
por: Aqel, Saba I., et al.
Publicado: (2021)

GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells
por: Moon, Jeonghyeon, et al.
Publicado: (2020)

Artesunate influences Th17/Treg lymphocyte balance by modulating Treg apoptosis and Th17 proliferation in a murine model of rheumatoid arthritis
por: Liu, Jia, et al.
Publicado: (2017)

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB
por: Symons, Antony, et al.
Publicado: (2017)

Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection
por: Ye, Qing, et al.
Publicado: (2017)

The correlation between the Th17/Treg cell balance and bone health
por: Zhu, Lei, et al.
Publicado: (2020)

Th17 and Treg Balance in Children With Obesity and Metabolically Altered Status
por: Calcaterra, Valeria, et al.
Publicado: (2020)

Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis
por: Huang, Fei, et al.
Publicado: (2022)

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance
por: Zhou, Yan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8minm59hrot0ot0qp4rmr10dee