Cargando…
Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells
BACKGROUND: Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the action of UA remain largely unknown. METHODS: Cell viability was measured by MTT ass...
Autores principales: | Wu, Jingjing, Zhao, Shunyu, Tang, Qing, Zheng, Fang, Chen, YuQin, Yang, LiJun, Yang, Xiaobing, Li, Liuning, Wu, WanYin, Hann, Swei Sunny |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567809/ https://www.ncbi.nlm.nih.gov/pubmed/26362062 http://dx.doi.org/10.1186/s13046-015-0215-9 |
Ejemplares similares
-
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
por: Li, Longmei, et al.
Publicado: (2016) -
β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1
por: Zhao, ShunYu, et al.
Publicado: (2015) -
Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
por: Zheng, Fang, et al.
Publicado: (2015) -
p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine
por: Zheng, Fang, et al.
Publicado: (2014) -
Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
por: Li, Jing, et al.
Publicado: (2015)