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Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes

BACKGROUND: Bisphenol A (BPA) and phthalates are ubiquitous non-persistent endocrine disrupting chemicals whose relation with infant birth size is not clearly understood. METHODS: We examined associations between maternal and paternal preconception urinary concentrations of total BPA and 14 phthalat...

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Autores principales: Smarr, Melissa M., Grantz, Katherine L., Sundaram, Rajeshwari, Maisog, José M., Kannan, Kurunthachalam, Louis, Germaine M. Buck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567813/
https://www.ncbi.nlm.nih.gov/pubmed/26362861
http://dx.doi.org/10.1186/s12940-015-0060-5
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author Smarr, Melissa M.
Grantz, Katherine L.
Sundaram, Rajeshwari
Maisog, José M.
Kannan, Kurunthachalam
Louis, Germaine M. Buck
author_facet Smarr, Melissa M.
Grantz, Katherine L.
Sundaram, Rajeshwari
Maisog, José M.
Kannan, Kurunthachalam
Louis, Germaine M. Buck
author_sort Smarr, Melissa M.
collection PubMed
description BACKGROUND: Bisphenol A (BPA) and phthalates are ubiquitous non-persistent endocrine disrupting chemicals whose relation with infant birth size is not clearly understood. METHODS: We examined associations between maternal and paternal preconception urinary concentrations of total BPA and 14 phthalate metabolites and birth size for 233 infants. Multiple linear regression models were used to estimate parental quartiles of BPA and phthalates in relation to birth weight, length, head circumference, and ponderal index with separate models run for each parent adjusting for age, smoking, body mass index, education, alcohol, parity, and creatinine. Models also included an interaction term for each chemical and infant sex and were further adjusted to include the other partner’s chemical concentrations. RESULTS: In maternal models adjusted for partner’s exposure and covariates, reductions in birth weight (range: 178-215 g; p < 0.05) were observed for the 2(nd) quartile of maternal monomethyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate and mono-n-octyl phthalate when compared with the 1(st) quartiles. The 3(rd) quartile of monoethylhexyl phthalate (mEHP) was also associated with a 200.16 g (95 % CI: -386.90, -13.42) reduction. Similar reductions in birth weight were observed for the 2(nd) quartile of paternal mEHP (β = -191.93 g; 95 % CI: -381.61, -2.25). Additionally, select maternal urinary metabolites were associated with decreased head circumference, birth length and gestational age. However, paternal concentrations were generally associated with increased birth length and gestational age. CONCLUSIONS: We observed some suggestion that preconception maternal and paternal urinary concentration of BPA and specific phthalate metabolites may be associated with smaller birth size and increased gestational age, though the findings appeared to be parent and chemical specific. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12940-015-0060-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-45678132015-09-13 Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes Smarr, Melissa M. Grantz, Katherine L. Sundaram, Rajeshwari Maisog, José M. Kannan, Kurunthachalam Louis, Germaine M. Buck Environ Health Research BACKGROUND: Bisphenol A (BPA) and phthalates are ubiquitous non-persistent endocrine disrupting chemicals whose relation with infant birth size is not clearly understood. METHODS: We examined associations between maternal and paternal preconception urinary concentrations of total BPA and 14 phthalate metabolites and birth size for 233 infants. Multiple linear regression models were used to estimate parental quartiles of BPA and phthalates in relation to birth weight, length, head circumference, and ponderal index with separate models run for each parent adjusting for age, smoking, body mass index, education, alcohol, parity, and creatinine. Models also included an interaction term for each chemical and infant sex and were further adjusted to include the other partner’s chemical concentrations. RESULTS: In maternal models adjusted for partner’s exposure and covariates, reductions in birth weight (range: 178-215 g; p < 0.05) were observed for the 2(nd) quartile of maternal monomethyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate and mono-n-octyl phthalate when compared with the 1(st) quartiles. The 3(rd) quartile of monoethylhexyl phthalate (mEHP) was also associated with a 200.16 g (95 % CI: -386.90, -13.42) reduction. Similar reductions in birth weight were observed for the 2(nd) quartile of paternal mEHP (β = -191.93 g; 95 % CI: -381.61, -2.25). Additionally, select maternal urinary metabolites were associated with decreased head circumference, birth length and gestational age. However, paternal concentrations were generally associated with increased birth length and gestational age. CONCLUSIONS: We observed some suggestion that preconception maternal and paternal urinary concentration of BPA and specific phthalate metabolites may be associated with smaller birth size and increased gestational age, though the findings appeared to be parent and chemical specific. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12940-015-0060-5) contains supplementary material, which is available to authorized users. BioMed Central 2015-09-11 /pmc/articles/PMC4567813/ /pubmed/26362861 http://dx.doi.org/10.1186/s12940-015-0060-5 Text en © Smarr et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Smarr, Melissa M.
Grantz, Katherine L.
Sundaram, Rajeshwari
Maisog, José M.
Kannan, Kurunthachalam
Louis, Germaine M. Buck
Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title_full Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title_fullStr Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title_full_unstemmed Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title_short Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes
title_sort parental urinary biomarkers of preconception exposure to bisphenol a and phthalates in relation to birth outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567813/
https://www.ncbi.nlm.nih.gov/pubmed/26362861
http://dx.doi.org/10.1186/s12940-015-0060-5
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