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Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

BACKGROUND: Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is r...

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Detalles Bibliográficos
Autores principales:	Kim, Baek, Stephen, Sam L., Hanby, Andrew M., Horgan, Kieran, Perry, Sarah L., Richardson, Julie, Roundhill, Elizabeth A., Valleley, Elizabeth M. A., Verghese, Eldo T., Williams, Bethany J., Thorne, James L., Hughes, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567818/ https://www.ncbi.nlm.nih.gov/pubmed/26362310 http://dx.doi.org/10.1186/s12885-015-1625-y

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