Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma

BACKGROUND: Global deregulation of DNA methylation is one of the crucial causes of hepato cellular carcinoma (HCC). It has been reported that the anti-cancer drug 5-azacytidine (5-AZA) mediates the activation of tumor suppressor genes through passive demethylation by inhibiting DNMT1. Recent evidenc...

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Detalles Bibliográficos
Autores principales: Sajadian, Sahar Olsadat, Ehnert, Sabrina, Vakilian, Haghighat, Koutsouraki, Eirini, Damm, Georg, Seehofer, Daniel, Thasler, Wolfgang, Dooley, Steven, Baharvand, Hossein, Sipos, Bence, Nussler, Andreas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567821/
https://www.ncbi.nlm.nih.gov/pubmed/26366235
http://dx.doi.org/10.1186/s13148-015-0133-x

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