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Anoctamin-1 Cl(−) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01
BACKGROUND: Anoctamin 1 (ANO1 or TMEM16A) Ca(2+)-gated Cl(−) channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl(−) concentrations ([Cl(−)](i)) sensory neuronal Cl(−) channels are excitatory. The ability of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567824/ https://www.ncbi.nlm.nih.gov/pubmed/26364309 http://dx.doi.org/10.1186/s12990-015-0061-y |