Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.

ABSTRACT: Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known...

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Detalles Bibliográficos
Autores principales: Wen, Hao, Li, Yan, Liu, Xingzhong, Ye, Wencai, Yao, Xinsheng, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567992/
https://www.ncbi.nlm.nih.gov/pubmed/26329590
http://dx.doi.org/10.1007/s13659-015-0067-1
Descripción
Sumario:ABSTRACT: Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1–6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0067-1) contains supplementary material, which is available to authorized users.

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