Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.

ABSTRACT: Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known...

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Autores principales: Wen, Hao, Li, Yan, Liu, Xingzhong, Ye, Wencai, Yao, Xinsheng, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567992/
https://www.ncbi.nlm.nih.gov/pubmed/26329590
http://dx.doi.org/10.1007/s13659-015-0067-1
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author Wen, Hao
Li, Yan
Liu, Xingzhong
Ye, Wencai
Yao, Xinsheng
Che, Yongsheng
author_facet Wen, Hao
Li, Yan
Liu, Xingzhong
Ye, Wencai
Yao, Xinsheng
Che, Yongsheng
author_sort Wen, Hao
collection PubMed
description ABSTRACT: Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1–6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0067-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-45679922015-09-15 Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp. Wen, Hao Li, Yan Liu, Xingzhong Ye, Wencai Yao, Xinsheng Che, Yongsheng Nat Prod Bioprospect Original Article ABSTRACT: Fusagerins A–F (1–6), six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety (1), a hydantoin (imidazolidin-2,4-dione) derivative (2), and four fungerin analogues (3–6), were isolated from the crude extract of the fungus Fusarium sp., together with the known compound fungerin (7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1–6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0067-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-09-02 /pmc/articles/PMC4567992/ /pubmed/26329590 http://dx.doi.org/10.1007/s13659-015-0067-1 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Wen, Hao
Li, Yan
Liu, Xingzhong
Ye, Wencai
Yao, Xinsheng
Che, Yongsheng
Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title_full Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title_fullStr Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title_full_unstemmed Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title_short Fusagerins A–F, New Alkaloids from the Fungus Fusarium sp.
title_sort fusagerins a–f, new alkaloids from the fungus fusarium sp.
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567992/
https://www.ncbi.nlm.nih.gov/pubmed/26329590
http://dx.doi.org/10.1007/s13659-015-0067-1
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