Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological m...

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Autores principales: Karaderi, Tugce, Drong, Alexander W., Lindgren, Cecilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Genetics (AP Morris, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568008/
https://www.ncbi.nlm.nih.gov/pubmed/26363598
http://dx.doi.org/10.1007/s11892-015-0648-8
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author Karaderi, Tugce
Drong, Alexander W.
Lindgren, Cecilia M.
author_facet Karaderi, Tugce
Drong, Alexander W.
Lindgren, Cecilia M.
author_sort Karaderi, Tugce
collection PubMed
description Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.
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spelling pubmed-45680082015-09-15 Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits Karaderi, Tugce Drong, Alexander W. Lindgren, Cecilia M. Curr Diab Rep Genetics (AP Morris, Section Editor) Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility. Springer US 2015-09-12 2015 /pmc/articles/PMC4568008/ /pubmed/26363598 http://dx.doi.org/10.1007/s11892-015-0648-8 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Genetics (AP Morris, Section Editor)
Karaderi, Tugce
Drong, Alexander W.
Lindgren, Cecilia M.
Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title_full Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title_fullStr Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title_full_unstemmed Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title_short Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
title_sort insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of obesity-related traits
topic Genetics (AP Morris, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568008/
https://www.ncbi.nlm.nih.gov/pubmed/26363598
http://dx.doi.org/10.1007/s11892-015-0648-8
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