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Proteins of Bartonella bacilliformis: Candidates for Vaccine Development
Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568041/ https://www.ncbi.nlm.nih.gov/pubmed/26413097 http://dx.doi.org/10.1155/2015/702784 |
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author | Henriquez-Camacho, Cesar Ventosilla, Palmira Minnick, Michael F. Ruiz, Joaquim Maguiña, Ciro |
author_facet | Henriquez-Camacho, Cesar Ventosilla, Palmira Minnick, Michael F. Ruiz, Joaquim Maguiña, Ciro |
author_sort | Henriquez-Camacho, Cesar |
collection | PubMed |
description | Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine. |
format | Online Article Text |
id | pubmed-4568041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45680412015-09-27 Proteins of Bartonella bacilliformis: Candidates for Vaccine Development Henriquez-Camacho, Cesar Ventosilla, Palmira Minnick, Michael F. Ruiz, Joaquim Maguiña, Ciro Int J Pept Review Article Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine. Hindawi Publishing Corporation 2015 2015-08-30 /pmc/articles/PMC4568041/ /pubmed/26413097 http://dx.doi.org/10.1155/2015/702784 Text en Copyright © 2015 Cesar Henriquez-Camacho et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Henriquez-Camacho, Cesar Ventosilla, Palmira Minnick, Michael F. Ruiz, Joaquim Maguiña, Ciro Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title | Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title_full | Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title_fullStr | Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title_full_unstemmed | Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title_short | Proteins of Bartonella bacilliformis: Candidates for Vaccine Development |
title_sort | proteins of bartonella bacilliformis: candidates for vaccine development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568041/ https://www.ncbi.nlm.nih.gov/pubmed/26413097 http://dx.doi.org/10.1155/2015/702784 |
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