Guanylate-binding proteins promote AIM2 inflammasome activation during Francisella novicida infection by inducing cytosolic bacteriolysis and DNA release

The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines IL-1β and IL-18. AIM2 is critical for host defense against DNA viruses and bacteria that replicate in the cytosol, such as Francisella novicida...

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Detalles Bibliográficos
Autores principales: Meunier, Etienne, Wallet, Pierre, Dreier, Roland F., Costanzo, Stéphanie, Anton, Leonie, Rühl, Sebastian, Dussurgey, Sébastien, Dick, Mathias S., Kistner, Anne, Rigard, Mélanie, Degrandi, Daniel, Pfeffer, Klaus, Yamamoto, Masahiro, Henry, Thomas, Broz, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568307/
https://www.ncbi.nlm.nih.gov/pubmed/25774716
http://dx.doi.org/10.1038/ni.3119

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