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Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain

Regenerative capacity of the brain is a variable trait within animals. Aquatic vertebrates such as zebrafish have widespread ability to renew their brains upon damage, while mammals have—if not none—very limited overall regenerative competence. Underlying cause of such a disparity is not fully evide...

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Detalles Bibliográficos
Autores principales: Cosacak, Mehmet Ilyas, Papadimitriou, Christos, Kizil, Caghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568348/
https://www.ncbi.nlm.nih.gov/pubmed/26417601
http://dx.doi.org/10.1155/2015/769763
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author Cosacak, Mehmet Ilyas
Papadimitriou, Christos
Kizil, Caghan
author_facet Cosacak, Mehmet Ilyas
Papadimitriou, Christos
Kizil, Caghan
author_sort Cosacak, Mehmet Ilyas
collection PubMed
description Regenerative capacity of the brain is a variable trait within animals. Aquatic vertebrates such as zebrafish have widespread ability to renew their brains upon damage, while mammals have—if not none—very limited overall regenerative competence. Underlying cause of such a disparity is not fully evident; however, one of the reasons could be activation of peculiar molecular programs, which might have specific roles after injury or damage, by the organisms that regenerate. If this hypothesis is correct, then there must be genes and pathways that (a) are expressed only after injury or damage in tissues, (b) are biologically and functionally relevant to restoration of neural tissue, and (c) are not detected in regenerating organisms. Presence of such programs might circumvent the initial detrimental effects of the damage and subsequently set up the stage for tissue redevelopment to take place by modulating the plasticity of the neural stem/progenitor cells. Additionally, if transferable, those “molecular mechanisms of regeneration” could open up new avenues for regenerative therapies of humans in clinical settings. This review focuses on the recent studies addressing injury/damage-induced molecular programs in zebrafish brain, underscoring the possibility of the presence of genes that could be used as biomarkers of neural plasticity and regeneration.
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spelling pubmed-45683482015-09-28 Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain Cosacak, Mehmet Ilyas Papadimitriou, Christos Kizil, Caghan Biomed Res Int Review Article Regenerative capacity of the brain is a variable trait within animals. Aquatic vertebrates such as zebrafish have widespread ability to renew their brains upon damage, while mammals have—if not none—very limited overall regenerative competence. Underlying cause of such a disparity is not fully evident; however, one of the reasons could be activation of peculiar molecular programs, which might have specific roles after injury or damage, by the organisms that regenerate. If this hypothesis is correct, then there must be genes and pathways that (a) are expressed only after injury or damage in tissues, (b) are biologically and functionally relevant to restoration of neural tissue, and (c) are not detected in regenerating organisms. Presence of such programs might circumvent the initial detrimental effects of the damage and subsequently set up the stage for tissue redevelopment to take place by modulating the plasticity of the neural stem/progenitor cells. Additionally, if transferable, those “molecular mechanisms of regeneration” could open up new avenues for regenerative therapies of humans in clinical settings. This review focuses on the recent studies addressing injury/damage-induced molecular programs in zebrafish brain, underscoring the possibility of the presence of genes that could be used as biomarkers of neural plasticity and regeneration. Hindawi Publishing Corporation 2015 2015-08-31 /pmc/articles/PMC4568348/ /pubmed/26417601 http://dx.doi.org/10.1155/2015/769763 Text en Copyright © 2015 Mehmet Ilyas Cosacak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cosacak, Mehmet Ilyas
Papadimitriou, Christos
Kizil, Caghan
Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title_full Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title_fullStr Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title_full_unstemmed Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title_short Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
title_sort regeneration, plasticity, and induced molecular programs in adult zebrafish brain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568348/
https://www.ncbi.nlm.nih.gov/pubmed/26417601
http://dx.doi.org/10.1155/2015/769763
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