Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing...

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Detalles Bibliográficos
Autores principales: Lin, Kailin, Chen, Song, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568416/
https://www.ncbi.nlm.nih.gov/pubmed/26441978
http://dx.doi.org/10.3389/fimmu.2015.00473
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author Lin, Kailin
Chen, Song
Chen, Gang
author_facet Lin, Kailin
Chen, Song
Chen, Gang
author_sort Lin, Kailin
collection PubMed
description Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.
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spelling pubmed-45684162015-10-05 Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation Lin, Kailin Chen, Song Chen, Gang Front Immunol Immunology Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes. Frontiers Media S.A. 2015-09-14 /pmc/articles/PMC4568416/ /pubmed/26441978 http://dx.doi.org/10.3389/fimmu.2015.00473 Text en Copyright © 2015 Lin, Chen and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lin, Kailin
Chen, Song
Chen, Gang
Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title_full Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title_fullStr Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title_full_unstemmed Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title_short Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation
title_sort role of memory t cells and perspectives for intervention in organ transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568416/
https://www.ncbi.nlm.nih.gov/pubmed/26441978
http://dx.doi.org/10.3389/fimmu.2015.00473
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