In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

Spectinamides are new semi-synthetic spectinomycin derivatives with potent anti-tubercular activity. The reported synergism of the precursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M. tuberculosis to other antibiotics not traditionally used in the...

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Detalles Bibliográficos
Autores principales: Bruhn, David F., Scherman, Michael S., Liu, Jiuyu, Scherbakov, Dimitri, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J., Lee, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568539/
https://www.ncbi.nlm.nih.gov/pubmed/26365087
http://dx.doi.org/10.1038/srep13985

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