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Small molecule inhibition of Csk alters affinity recognition by T cells

The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling, we utilized a mouse expressing mutated Csk (Csk(...

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Detalles Bibliográficos
Autores principales:	Manz, Boryana N, Tan, Ying Xim, Courtney, Adam H, Rutaganira, Florentine, Palmer, Ed, Shokat, Kevan M, Weiss, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568592/ https://www.ncbi.nlm.nih.gov/pubmed/26302204 http://dx.doi.org/10.7554/eLife.08088

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