Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron–Sulfur Enzyme in Pathogenic Bacteria

[Image: see text] The recently discovered methylerythritol phosphate (MEP) pathway provides new targets for the development of antibacterial and antimalarial drugs. In the final step of the MEP pathway, the [4Fe–4S] IspH protein catalyzes the 2e(–)/2H(+) reductive dehydroxylation of (E)-4-hydroxy-3-...

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Detalles Bibliográficos
Autores principales: Blachly, Patrick G., Sandala, Gregory M., Giammona, Debra Ann, Bashford, Donald, McCammon, J. Andrew, Noodleman, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568833/
https://www.ncbi.nlm.nih.gov/pubmed/26098647
http://dx.doi.org/10.1021/acs.inorgchem.5b00751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568833/
https://www.ncbi.nlm.nih.gov/pubmed/26098647
http://dx.doi.org/10.1021/acs.inorgchem.5b00751

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