Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non-cell autonomously to rod photoreceptor degeneration by primary phagocytosis of living rods. Using rd10 mice, we found that the in...

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Detalles Bibliográficos
Autores principales: Zhao, Lian, Zabel, Matthew K, Wang, Xu, Ma, Wenxin, Shah, Parth, Fariss, Robert N, Qian, Haohua, Parkhurst, Christopher N, Gan, Wen-Biao, Wong, Wai T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568951/
https://www.ncbi.nlm.nih.gov/pubmed/26139610
http://dx.doi.org/10.15252/emmm.201505298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568951/
https://www.ncbi.nlm.nih.gov/pubmed/26139610
http://dx.doi.org/10.15252/emmm.201505298

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