Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans

Insight into the maintenance of naive T cells is essential to understand defective immune responses in the context of aging and other immune compromised states. In humans, naive CD4+ T cells, in contrast to CD8+ T cells, are remarkably well retained with aging. Here, we show that low-affinity TCR en...

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Detalles Bibliográficos
Autores principales: van der Geest, Kornelis S M, Abdulahad, Wayel H, Teteloshvili, Nato, Tete, Sarah M, Peters, Jorieke H, Horst, Gerda, Lorencetti, Pedro G, Bos, Nicolaas A, Lambeck, Annechien, Roozendaal, Caroline, Kroesen, Bart-Jan, Koenen, Hans J P M, Joosten, Irma, Brouwer, Elisabeth, Boots, Annemieke M H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568962/
https://www.ncbi.nlm.nih.gov/pubmed/26010129
http://dx.doi.org/10.1111/acel.12353

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