Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

[Image: see text] Protein arginine deiminases (PADs) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine resi...

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Detalles Bibliográficos
Autores principales: Slade, Daniel J., Fang, Pengfei, Dreyton, Christina J., Zhang, Ying, Fuhrmann, Jakob, Rempel, Don, Bax, Benjamin D., Coonrod, Scott A., Lewis, Huw D., Guo, Min, Gross, Michael L., Thompson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569063/
https://www.ncbi.nlm.nih.gov/pubmed/25621824
http://dx.doi.org/10.1021/cb500933j

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