Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation, focused or converging visible light readily reache...

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Detalles Bibliográficos
Autores principales: de Lange, Mark J., Razzaq, Lubna, Versluis, Mieke, Verlinde, Sven, Dogrusöz, Mehmet, Böhringer, Stefan, Marinkovic, Marina, Luyten, Gregorius P. M., de Keizer, Rob J. W., de Gruijl, Frank R., Jager, Martine J., van der Velden, Pieter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569098/
https://www.ncbi.nlm.nih.gov/pubmed/26368812
http://dx.doi.org/10.1371/journal.pone.0138002

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