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Silica particles cause NADPH oxidase–independent ROS generation and transient phagolysosomal leakage

Chronic inhalation of silica particles causes lung fibrosis and silicosis. Silica taken up by alveolar macrophages causes phagolysosomal membrane damage and leakage of lysosomal material into the cytoplasm to initiate apoptosis. We investigated the role of reactive oxygen species (ROS) in this membr...

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Detalles Bibliográficos
Autores principales:	Joshi, Gaurav N., Goetjen, Alexandra M., Knecht, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569308/ https://www.ncbi.nlm.nih.gov/pubmed/26202463 http://dx.doi.org/10.1091/mbc.E15-03-0126

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