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Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction

Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these finding...

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Autores principales: Shushimita, Shushimita, van der Pol, Pieter, W.F. de Bruin, Ron, N. M. Ijzermans, Jan, van Kooten, Cees, Dor, Frank J. M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569339/
https://www.ncbi.nlm.nih.gov/pubmed/26367533
http://dx.doi.org/10.1371/journal.pone.0137795
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author Shushimita, Shushimita
van der Pol, Pieter
W.F. de Bruin, Ron
N. M. Ijzermans, Jan
van Kooten, Cees
Dor, Frank J. M. F.
author_facet Shushimita, Shushimita
van der Pol, Pieter
W.F. de Bruin, Ron
N. M. Ijzermans, Jan
van Kooten, Cees
Dor, Frank J. M. F.
author_sort Shushimita, Shushimita
collection PubMed
description Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10–12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different.
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spelling pubmed-45693392015-09-18 Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction Shushimita, Shushimita van der Pol, Pieter W.F. de Bruin, Ron N. M. Ijzermans, Jan van Kooten, Cees Dor, Frank J. M. F. PLoS One Research Article Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10–12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different. Public Library of Science 2015-09-14 /pmc/articles/PMC4569339/ /pubmed/26367533 http://dx.doi.org/10.1371/journal.pone.0137795 Text en © 2015 Shushimita et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shushimita, Shushimita
van der Pol, Pieter
W.F. de Bruin, Ron
N. M. Ijzermans, Jan
van Kooten, Cees
Dor, Frank J. M. F.
Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title_full Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title_fullStr Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title_full_unstemmed Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title_short Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
title_sort mannan-binding lectin is involved in the protection against renal ischemia/reperfusion injury by dietary restriction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569339/
https://www.ncbi.nlm.nih.gov/pubmed/26367533
http://dx.doi.org/10.1371/journal.pone.0137795
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