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Critical Function of γH2A in S-Phase
Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clastogens, but recent studies suggest that DNA replicat...
Autores principales: | Mejia-Ramirez, Eva, Limbo, Oliver, Langerak, Petra, Russell, Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569340/ https://www.ncbi.nlm.nih.gov/pubmed/26368543 http://dx.doi.org/10.1371/journal.pgen.1005517 |
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