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Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells

Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrP(Sc)) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrP(Sc), we investigated the role of autophagy in its degradation, usi...

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Detalles Bibliográficos
Autores principales:	Ishibashi, Daisuke, Homma, Takujiro, Nakagaki, Takehiro, Fuse, Takayuki, Sano, Kazunori, Takatsuki, Hanae, Atarashi, Ryuichiro, Nishida, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569470/ https://www.ncbi.nlm.nih.gov/pubmed/26368533 http://dx.doi.org/10.1371/journal.pone.0137958

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