Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells

Chondrosarcomas are malignant bone tumors that produce cartilaginous matrix. Mutations in isocitrate dehydrogenase enzymes (IDH1/2) were recently described in several cancers including chondrosarcomas. The IDH1 inhibitor AGI-5198 abrogates the ability of mutant IDH1 to produce the oncometabolite D-2...

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Detalles Bibliográficos
Autores principales: Li, Luyuan, Paz, Ana C., Wilky, Breelyn A., Johnson, Britt, Galoian, Karina, Rosenberg, Andrew, Hu, Guozhi, Tinoco, Gabriel, Bodamer, Olaf, Trent, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569544/
https://www.ncbi.nlm.nih.gov/pubmed/26368816
http://dx.doi.org/10.1371/journal.pone.0133813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569544/
https://www.ncbi.nlm.nih.gov/pubmed/26368816
http://dx.doi.org/10.1371/journal.pone.0133813

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