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Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users
Neurophysiological studies in animals and humans suggest that severe hearing loss during early development impairs the maturation of the auditory brainstem. To date, studies in humans have mainly focused on the neural activation of the auditory brainstem in children treated with a cochlear implant (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569605/ https://www.ncbi.nlm.nih.gov/pubmed/26162414 http://dx.doi.org/10.1007/s10162-015-0532-x |
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author | Lammers, Marc J. W. van Eijl, Ruben H. M. van Zanten, Gijsbert A. Versnel, Huib Grolman, Wilko |
author_facet | Lammers, Marc J. W. van Eijl, Ruben H. M. van Zanten, Gijsbert A. Versnel, Huib Grolman, Wilko |
author_sort | Lammers, Marc J. W. |
collection | PubMed |
description | Neurophysiological studies in animals and humans suggest that severe hearing loss during early development impairs the maturation of the auditory brainstem. To date, studies in humans have mainly focused on the neural activation of the auditory brainstem in children treated with a cochlear implant (CI), but little is known about the pattern of activation in adult CI users with early onset of deafness (prelingual, before the age of 2 years). In this study, we compare auditory brainstem activation in prelingually deaf and late-implanted adult CI users to that in postlingually deaf CI users. Electrically evoked auditory brainstem responses (eABRs) were recorded by monopolar stimulation, separately using a middle and an apical electrode of the CI. Comparison of the eABR latencies revealed that wave V was significantly delayed in the prelingually deaf CI users on both electrode locations. Accordingly, when the apical electrode was stimulated, the III–V interwave interval was significantly longer in the prelingually deaf group. These findings suggest a slower neural conduction in the auditory brainstem, probably caused by impairment of maturation during the long duration of severe hearing loss in infancy. Shorter wave V latencies, reflecting a more mature brainstem, appeared to be a predictor for better speech perception. |
format | Online Article Text |
id | pubmed-4569605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-45696052015-09-17 Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users Lammers, Marc J. W. van Eijl, Ruben H. M. van Zanten, Gijsbert A. Versnel, Huib Grolman, Wilko J Assoc Res Otolaryngol Research Article Neurophysiological studies in animals and humans suggest that severe hearing loss during early development impairs the maturation of the auditory brainstem. To date, studies in humans have mainly focused on the neural activation of the auditory brainstem in children treated with a cochlear implant (CI), but little is known about the pattern of activation in adult CI users with early onset of deafness (prelingual, before the age of 2 years). In this study, we compare auditory brainstem activation in prelingually deaf and late-implanted adult CI users to that in postlingually deaf CI users. Electrically evoked auditory brainstem responses (eABRs) were recorded by monopolar stimulation, separately using a middle and an apical electrode of the CI. Comparison of the eABR latencies revealed that wave V was significantly delayed in the prelingually deaf CI users on both electrode locations. Accordingly, when the apical electrode was stimulated, the III–V interwave interval was significantly longer in the prelingually deaf group. These findings suggest a slower neural conduction in the auditory brainstem, probably caused by impairment of maturation during the long duration of severe hearing loss in infancy. Shorter wave V latencies, reflecting a more mature brainstem, appeared to be a predictor for better speech perception. Springer US 2015-07-11 2015-10 /pmc/articles/PMC4569605/ /pubmed/26162414 http://dx.doi.org/10.1007/s10162-015-0532-x Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Article Lammers, Marc J. W. van Eijl, Ruben H. M. van Zanten, Gijsbert A. Versnel, Huib Grolman, Wilko Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title | Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title_full | Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title_fullStr | Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title_full_unstemmed | Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title_short | Delayed Auditory Brainstem Responses in Prelingually Deaf and Late-Implanted Cochlear Implant Users |
title_sort | delayed auditory brainstem responses in prelingually deaf and late-implanted cochlear implant users |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569605/ https://www.ncbi.nlm.nih.gov/pubmed/26162414 http://dx.doi.org/10.1007/s10162-015-0532-x |
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