IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation

RNA virus infection is recognized by the RIG-I family of receptors that activate the mitochondrial adaptor MAVS, leading to the clearance of viruses. Antiviral signalling activation requires strict modulation to avoid damage to the host from exacerbated inflammation. Insulin receptor tyrosine kinase...

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Detalles Bibliográficos
Autores principales: Xia, Pengyan, Wang, Shuo, Xiong, Zhen, Ye, Buqing, Huang, Li-Yu, Han, Ze-Guang, Fan, Zusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569712/
https://www.ncbi.nlm.nih.gov/pubmed/26348439
http://dx.doi.org/10.1038/ncomms9132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569712/
https://www.ncbi.nlm.nih.gov/pubmed/26348439
http://dx.doi.org/10.1038/ncomms9132

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