Cargando…

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krarup, Anders, Truan, Daphné, Furmanova-Hollenstein, Polina, Bogaert, Lies, Bouchier, Pascale, Bisschop, Ilona J. M., Widjojoatmodjo, Myra N., Zahn, Roland, Schuitemaker, Hanneke, McLellan, Jason S., Langedijk, Johannes P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569726/ https://www.ncbi.nlm.nih.gov/pubmed/26333350 http://dx.doi.org/10.1038/ncomms9143

Ejemplares similares

Transient opening of trimeric prefusion RSV F proteins
por: Gilman, Morgan S. A., et al.
Publicado: (2019)

Adenovector 26 encoded prefusion conformation stabilized RSV-F protein induces long-lasting Th1-biased immunity in neonatal mice
por: van der Fits, Leslie, et al.
Publicado: (2020)

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies
por: Jones, Harrison G., et al.
Publicado: (2018)

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
por: Rutten, Lucy, et al.
Publicado: (2020)

Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines
por: Isaacs, Ariel, et al.
Publicado: (2021)

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein
por: Gilman, Morgan S. A., et al.
Publicado: (2015)

RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models
por: Cox, Freek, et al.
Publicado: (2023)

Protection of calves by a prefusion-stabilized bovine RSV F vaccine
por: Zhang, Baoshan, et al.
Publicado: (2017)

The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation
por: Wrapp, Daniel, et al.
Publicado: (2019)

Fusing safety and efficacy: A maternal bivalent RSV prefusion F vaccine
por: Miller, Ann M., et al.
Publicado: (2023)

Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins
por: Hsieh, Ching-Lin, et al.
Publicado: (2022)

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
por: Wrapp, Daniel, et al.
Publicado: (2020)

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
por: Wrapp, Daniel, et al.
Publicado: (2020)

Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle
por: Rainho-Tomko, Jennifer N., et al.
Publicado: (2022)

A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F
por: Yi, Chunyan, et al.
Publicado: (2023)

Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein
por: Harshbarger, Wayne, et al.
Publicado: (2021)

The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors
por: Andreano, Emanuele, et al.
Publicado: (2021)

A Protective and Safe Intranasal RSV Vaccine Based on a Recombinant Prefusion-Like Form of the F Protein Bound to Bacterium-Like Particles
por: Rigter, Alan, et al.
Publicado: (2013)

1632. Bivalent RSV Prefusion F-Based Subunit Vaccine Generates High Neutralizing Titers in Older Adults
por: Fukushima, Yasushi, et al.
Publicado: (2023)

Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models
por: Saeland, Eirikur, et al.
Publicado: (2023)

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
por: Furmanova-Hollenstein, Polina, et al.
Publicado: (2013)

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures
por: Melero, Roberto, et al.
Publicado: (2020)

Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures
por: Melero, Roberto, et al.
Publicado: (2020)

Alternative conformations of a major antigenic site on RSV F
por: Jones, Harrison G., et al.
Publicado: (2019)

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
por: Bos, Rinke, et al.
Publicado: (2020)

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
por: Rossey, Iebe, et al.
Publicado: (2017)

1936. Efficacy of One Dose of the Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine (RSVPreF3 OA) in Adults ≥ 60 Years of Age Persists for 2 RSV Seasons
por: Ison, Michael G, et al.
Publicado: (2023)

2755. Phase 1/2, First-in-Human Study of the Safety, Tolerability, and Immunogenicity of an RSV Prefusion F-Based Subunit Vaccine Candidate
por: Schmoele-Thoma, Beate, et al.
Publicado: (2019)

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
por: Rossey, Iebe, et al.
Publicado: (2017)

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
por: Hsieh, Ching-Lin, et al.
Publicado: (2020)

Enhancing Anti-G Antibody Induction by a Live Single-Cycle Prefusion F—Expressing RSV Vaccine Improves In Vitro and In Vivo Efficacy
por: Lamichhane, Pramila, et al.
Publicado: (2022)

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
por: Hsieh, Ching-Lin, et al.
Publicado: (2020)

Phase 1/2a Safety and Immunogenicity of an Adenovirus 26 Vector Respiratory Syncytial Virus (RSV) Vaccine Encoding Prefusion F in Adults 18–50 Years and RSV-Seropositive Children 12–24 Months
por: Stuart, Arabella S V, et al.
Publicado: (2022)

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups
por: Hutchinson, Geoffrey, et al.
Publicado: (2022)

Architecture of the SARS coronavirus prefusion spike
por: Beniac, Daniel R, et al.
Publicado: (2006)

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
por: Milder, Fin J., et al.
Publicado: (2022)

Global molecular diversity of RSV – the “INFORM RSV” study
por: Langedijk, Annefleur C., et al.
Publicado: (2020)

1942. Potential Public Health Impact of Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Maternal Vaccine for Prevention of RSV among US Infants
por: Hanau, Ahuva, et al.
Publicado: (2023)

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
por: Roymans, Dirk, et al.
Publicado: (2017)

Adenovectors encoding RSV-F protein induce durable and mucosal immunity in macaques after two intramuscular administrations
por: Salisch, N. C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uft8lu8in5a494tdmn22ogsjl6