Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in no...

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Detalles Bibliográficos
Autores principales: Manna, Sugata, Kim, Jong Kyong, Baugé, Catherine, Cam, Margaret, Zhao, Yongmei, Shetty, Jyoti, Vacchio, Melanie S., Castro, Ehydel, Tran, Bao, Tessarollo, Lino, Bosselut, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569738/
https://www.ncbi.nlm.nih.gov/pubmed/26328764
http://dx.doi.org/10.1038/ncomms9152

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