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Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study

NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentration...

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Autores principales: Hajduková, Lenka, Sobek, Ondřej, Prchalová, Darina, Bílková, Zuzana, Koudelková, Martina, Lukášková, Jiřina, Matuchová, Inka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569754/
https://www.ncbi.nlm.nih.gov/pubmed/26421286
http://dx.doi.org/10.1155/2015/379071
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author Hajduková, Lenka
Sobek, Ondřej
Prchalová, Darina
Bílková, Zuzana
Koudelková, Martina
Lukášková, Jiřina
Matuchová, Inka
author_facet Hajduková, Lenka
Sobek, Ondřej
Prchalová, Darina
Bílková, Zuzana
Koudelková, Martina
Lukášková, Jiřina
Matuchová, Inka
author_sort Hajduková, Lenka
collection PubMed
description NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics.
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spelling pubmed-45697542015-09-29 Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study Hajduková, Lenka Sobek, Ondřej Prchalová, Darina Bílková, Zuzana Koudelková, Martina Lukášková, Jiřina Matuchová, Inka Biomed Res Int Research Article NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics. Hindawi Publishing Corporation 2015 2015-09-01 /pmc/articles/PMC4569754/ /pubmed/26421286 http://dx.doi.org/10.1155/2015/379071 Text en Copyright © 2015 Lenka Hajduková et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hajduková, Lenka
Sobek, Ondřej
Prchalová, Darina
Bílková, Zuzana
Koudelková, Martina
Lukášková, Jiřina
Matuchová, Inka
Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title_full Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title_fullStr Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title_full_unstemmed Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title_short Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
title_sort biomarkers of brain damage: s100b and nse concentrations in cerebrospinal fluid—a normative study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569754/
https://www.ncbi.nlm.nih.gov/pubmed/26421286
http://dx.doi.org/10.1155/2015/379071
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