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Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study
NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentration...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569754/ https://www.ncbi.nlm.nih.gov/pubmed/26421286 http://dx.doi.org/10.1155/2015/379071 |
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author | Hajduková, Lenka Sobek, Ondřej Prchalová, Darina Bílková, Zuzana Koudelková, Martina Lukášková, Jiřina Matuchová, Inka |
author_facet | Hajduková, Lenka Sobek, Ondřej Prchalová, Darina Bílková, Zuzana Koudelková, Martina Lukášková, Jiřina Matuchová, Inka |
author_sort | Hajduková, Lenka |
collection | PubMed |
description | NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics. |
format | Online Article Text |
id | pubmed-4569754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45697542015-09-29 Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study Hajduková, Lenka Sobek, Ondřej Prchalová, Darina Bílková, Zuzana Koudelková, Martina Lukášková, Jiřina Matuchová, Inka Biomed Res Int Research Article NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics. Hindawi Publishing Corporation 2015 2015-09-01 /pmc/articles/PMC4569754/ /pubmed/26421286 http://dx.doi.org/10.1155/2015/379071 Text en Copyright © 2015 Lenka Hajduková et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hajduková, Lenka Sobek, Ondřej Prchalová, Darina Bílková, Zuzana Koudelková, Martina Lukášková, Jiřina Matuchová, Inka Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title | Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title_full | Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title_fullStr | Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title_full_unstemmed | Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title_short | Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study |
title_sort | biomarkers of brain damage: s100b and nse concentrations in cerebrospinal fluid—a normative study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569754/ https://www.ncbi.nlm.nih.gov/pubmed/26421286 http://dx.doi.org/10.1155/2015/379071 |
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