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Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication

Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial f...

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Autores principales: Szatmári, Tünde, Ötvös, Rita, Hjerpe, Anders, Dobra, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569789/
https://www.ncbi.nlm.nih.gov/pubmed/26420915
http://dx.doi.org/10.1155/2015/796052
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author Szatmári, Tünde
Ötvös, Rita
Hjerpe, Anders
Dobra, Katalin
author_facet Szatmári, Tünde
Ötvös, Rita
Hjerpe, Anders
Dobra, Katalin
author_sort Szatmári, Tünde
collection PubMed
description Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.
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spelling pubmed-45697892015-09-29 Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication Szatmári, Tünde Ötvös, Rita Hjerpe, Anders Dobra, Katalin Dis Markers Review Article Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types. Hindawi Publishing Corporation 2015 2015-09-01 /pmc/articles/PMC4569789/ /pubmed/26420915 http://dx.doi.org/10.1155/2015/796052 Text en Copyright © 2015 Tünde Szatmári et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Szatmári, Tünde
Ötvös, Rita
Hjerpe, Anders
Dobra, Katalin
Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title_full Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title_fullStr Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title_full_unstemmed Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title_short Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
title_sort syndecan-1 in cancer: implications for cell signaling, differentiation, and prognostication
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569789/
https://www.ncbi.nlm.nih.gov/pubmed/26420915
http://dx.doi.org/10.1155/2015/796052
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