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Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569789/ https://www.ncbi.nlm.nih.gov/pubmed/26420915 http://dx.doi.org/10.1155/2015/796052 |
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author | Szatmári, Tünde Ötvös, Rita Hjerpe, Anders Dobra, Katalin |
author_facet | Szatmári, Tünde Ötvös, Rita Hjerpe, Anders Dobra, Katalin |
author_sort | Szatmári, Tünde |
collection | PubMed |
description | Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types. |
format | Online Article Text |
id | pubmed-4569789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45697892015-09-29 Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication Szatmári, Tünde Ötvös, Rita Hjerpe, Anders Dobra, Katalin Dis Markers Review Article Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types. Hindawi Publishing Corporation 2015 2015-09-01 /pmc/articles/PMC4569789/ /pubmed/26420915 http://dx.doi.org/10.1155/2015/796052 Text en Copyright © 2015 Tünde Szatmári et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Szatmári, Tünde Ötvös, Rita Hjerpe, Anders Dobra, Katalin Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title | Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title_full | Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title_fullStr | Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title_full_unstemmed | Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title_short | Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication |
title_sort | syndecan-1 in cancer: implications for cell signaling, differentiation, and prognostication |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569789/ https://www.ncbi.nlm.nih.gov/pubmed/26420915 http://dx.doi.org/10.1155/2015/796052 |
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