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Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil
Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. The use ofA. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (EOs). The aim of this paper is the iden...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569837/ https://www.ncbi.nlm.nih.gov/pubmed/26107187 http://dx.doi.org/10.1590/0074-02760140129 |
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author | Martínez-Díaz, Rafael Alberto Ibáñez-Escribano, Alexandra Burillo, Jesús Heras, Lorena de las del Prado, Gema Agulló-Ortuño, M Teresa Julio, Luis F González-Coloma, Azucena |
author_facet | Martínez-Díaz, Rafael Alberto Ibáñez-Escribano, Alexandra Burillo, Jesús Heras, Lorena de las del Prado, Gema Agulló-Ortuño, M Teresa Julio, Luis F González-Coloma, Azucena |
author_sort | Martínez-Díaz, Rafael Alberto |
collection | PubMed |
description | Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. The use ofA. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (EOs). The aim of this paper is the identification of the active components of the vapour pressure (VP) EO from a selected and cultivated A. absinthiumSpanish population (T2-11) against two parasitic protozoa with different metabolic pathways: Trypanosoma cruzi andTrichomonas vaginalis. VP showed activity on both parasites at the highest concentrations. The chromatographic fractionation of the VP T2-11 resulted in nine fractions (VLC1-9). The chemical composition of the fractions and the antiparasitic effects of fractions and their main compounds suggest that the activity of the VP is related with the presence oftrans-caryophyllene and dihydrochamazulene (main components of fractions VLC1 and VLC2 respectively). Additionally, the cytotoxicity of VP and fractions has been tested on several tumour and no tumour human cell lines. Fractions VLC1 and VLC2 were not cytotoxic against the nontumoural cell line HS5, suggesting selective antiparasitic activity for these two fractions. The VP and fractions inhibited the growth of human tumour cell lines in a dose-dependent manner. |
format | Online Article Text |
id | pubmed-4569837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-45698372015-09-15 Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil Martínez-Díaz, Rafael Alberto Ibáñez-Escribano, Alexandra Burillo, Jesús Heras, Lorena de las del Prado, Gema Agulló-Ortuño, M Teresa Julio, Luis F González-Coloma, Azucena Mem Inst Oswaldo Cruz Natural Product Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. The use ofA. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (EOs). The aim of this paper is the identification of the active components of the vapour pressure (VP) EO from a selected and cultivated A. absinthiumSpanish population (T2-11) against two parasitic protozoa with different metabolic pathways: Trypanosoma cruzi andTrichomonas vaginalis. VP showed activity on both parasites at the highest concentrations. The chromatographic fractionation of the VP T2-11 resulted in nine fractions (VLC1-9). The chemical composition of the fractions and the antiparasitic effects of fractions and their main compounds suggest that the activity of the VP is related with the presence oftrans-caryophyllene and dihydrochamazulene (main components of fractions VLC1 and VLC2 respectively). Additionally, the cytotoxicity of VP and fractions has been tested on several tumour and no tumour human cell lines. Fractions VLC1 and VLC2 were not cytotoxic against the nontumoural cell line HS5, suggesting selective antiparasitic activity for these two fractions. The VP and fractions inhibited the growth of human tumour cell lines in a dose-dependent manner. Instituto Oswaldo Cruz, Ministério da Saúde 2015-08 /pmc/articles/PMC4569837/ /pubmed/26107187 http://dx.doi.org/10.1590/0074-02760140129 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Natural Product Martínez-Díaz, Rafael Alberto Ibáñez-Escribano, Alexandra Burillo, Jesús Heras, Lorena de las del Prado, Gema Agulló-Ortuño, M Teresa Julio, Luis F González-Coloma, Azucena Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil |
title | Trypanocidal, trichomonacidal and cytotoxic components of cultivated
Artemisia absinthium Linnaeus (Asteraceae) essential
oil |
title_full | Trypanocidal, trichomonacidal and cytotoxic components of cultivated
Artemisia absinthium Linnaeus (Asteraceae) essential
oil |
title_fullStr | Trypanocidal, trichomonacidal and cytotoxic components of cultivated
Artemisia absinthium Linnaeus (Asteraceae) essential
oil |
title_full_unstemmed | Trypanocidal, trichomonacidal and cytotoxic components of cultivated
Artemisia absinthium Linnaeus (Asteraceae) essential
oil |
title_short | Trypanocidal, trichomonacidal and cytotoxic components of cultivated
Artemisia absinthium Linnaeus (Asteraceae) essential
oil |
title_sort | trypanocidal, trichomonacidal and cytotoxic components of cultivated
artemisia absinthium linnaeus (asteraceae) essential
oil |
topic | Natural Product |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569837/ https://www.ncbi.nlm.nih.gov/pubmed/26107187 http://dx.doi.org/10.1590/0074-02760140129 |
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