Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of human 7q22 a...

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Detalles Bibliográficos
Autores principales: Wong, Jasmine C, Weinfurtner, Kelley M, Alzamora, Maria del pilar, Kogan, Scott C, Burgess, Michael R, Zhang, Yan, Nakitandwe, Joy, Ma, Jing, Cheng, Jinjun, Chen, Shann-Ching, Ho, Theodore T, Flach, Johanna, Reynaud, Damien, Passegué, Emmanuelle, Downing, James R, Shannon, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569895/
https://www.ncbi.nlm.nih.gov/pubmed/26193121
http://dx.doi.org/10.7554/eLife.07839

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