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A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such em...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569900/ https://www.ncbi.nlm.nih.gov/pubmed/26370514 http://dx.doi.org/10.1038/srep14130 |
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author | Lazariev, Andrii Balasubramanian, Gopalakrishnan |
author_facet | Lazariev, Andrii Balasubramanian, Gopalakrishnan |
author_sort | Lazariev, Andrii |
collection | PubMed |
description | Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such emerging sensing method uses the spins associated with nitrogen-vacancy (NV) defects in diamond. The uniqueness of this NV sensor is its atomic size and ability to perform precision sensing under ambient conditions conveniently using light and microwaves (MW). These advantages have unique applications in nanoscale sensing and imaging of magnetic fields from nuclear spins in single biomolecules. During the last few years, several encouraging results have emerged towards the realization of an NV spin-based molecular structure microscope. Here, we present a projection-reconstruction method that retrieves the three-dimensional structure of a single molecule from the nuclear spin noise signatures. We validate this method using numerical simulations and reconstruct the structure of a molecular phantom β-cyclodextrin, revealing the characteristic toroidal shape. |
format | Online Article Text |
id | pubmed-4569900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45699002015-09-28 A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction Lazariev, Andrii Balasubramanian, Gopalakrishnan Sci Rep Article Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such emerging sensing method uses the spins associated with nitrogen-vacancy (NV) defects in diamond. The uniqueness of this NV sensor is its atomic size and ability to perform precision sensing under ambient conditions conveniently using light and microwaves (MW). These advantages have unique applications in nanoscale sensing and imaging of magnetic fields from nuclear spins in single biomolecules. During the last few years, several encouraging results have emerged towards the realization of an NV spin-based molecular structure microscope. Here, we present a projection-reconstruction method that retrieves the three-dimensional structure of a single molecule from the nuclear spin noise signatures. We validate this method using numerical simulations and reconstruct the structure of a molecular phantom β-cyclodextrin, revealing the characteristic toroidal shape. Nature Publishing Group 2015-09-15 /pmc/articles/PMC4569900/ /pubmed/26370514 http://dx.doi.org/10.1038/srep14130 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lazariev, Andrii Balasubramanian, Gopalakrishnan A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title | A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title_full | A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title_fullStr | A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title_full_unstemmed | A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title_short | A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
title_sort | nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569900/ https://www.ncbi.nlm.nih.gov/pubmed/26370514 http://dx.doi.org/10.1038/srep14130 |
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