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A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction

Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such em...

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Autores principales: Lazariev, Andrii, Balasubramanian, Gopalakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569900/
https://www.ncbi.nlm.nih.gov/pubmed/26370514
http://dx.doi.org/10.1038/srep14130
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author Lazariev, Andrii
Balasubramanian, Gopalakrishnan
author_facet Lazariev, Andrii
Balasubramanian, Gopalakrishnan
author_sort Lazariev, Andrii
collection PubMed
description Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such emerging sensing method uses the spins associated with nitrogen-vacancy (NV) defects in diamond. The uniqueness of this NV sensor is its atomic size and ability to perform precision sensing under ambient conditions conveniently using light and microwaves (MW). These advantages have unique applications in nanoscale sensing and imaging of magnetic fields from nuclear spins in single biomolecules. During the last few years, several encouraging results have emerged towards the realization of an NV spin-based molecular structure microscope. Here, we present a projection-reconstruction method that retrieves the three-dimensional structure of a single molecule from the nuclear spin noise signatures. We validate this method using numerical simulations and reconstruct the structure of a molecular phantom β-cyclodextrin, revealing the characteristic toroidal shape.
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spelling pubmed-45699002015-09-28 A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction Lazariev, Andrii Balasubramanian, Gopalakrishnan Sci Rep Article Methods and techniques to measure and image beyond the state-of-the-art have always been influential in propelling basic science and technology. Because current technologies are venturing into nanoscopic and molecular-scale fabrication, atomic-scale measurement techniques are inevitable. One such emerging sensing method uses the spins associated with nitrogen-vacancy (NV) defects in diamond. The uniqueness of this NV sensor is its atomic size and ability to perform precision sensing under ambient conditions conveniently using light and microwaves (MW). These advantages have unique applications in nanoscale sensing and imaging of magnetic fields from nuclear spins in single biomolecules. During the last few years, several encouraging results have emerged towards the realization of an NV spin-based molecular structure microscope. Here, we present a projection-reconstruction method that retrieves the three-dimensional structure of a single molecule from the nuclear spin noise signatures. We validate this method using numerical simulations and reconstruct the structure of a molecular phantom β-cyclodextrin, revealing the characteristic toroidal shape. Nature Publishing Group 2015-09-15 /pmc/articles/PMC4569900/ /pubmed/26370514 http://dx.doi.org/10.1038/srep14130 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lazariev, Andrii
Balasubramanian, Gopalakrishnan
A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title_full A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title_fullStr A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title_full_unstemmed A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title_short A nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
title_sort nitrogen-vacancy spin based molecular structure microscope using multiplexed projection reconstruction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569900/
https://www.ncbi.nlm.nih.gov/pubmed/26370514
http://dx.doi.org/10.1038/srep14130
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