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A metabolomics-based strategy for identification of gene targets for phenotype improvement and its application to 1-butanol tolerance in Saccharomyces cerevisiae
BACKGROUND: Traditional approaches to phenotype improvement include rational selection of genes for modification, and probability-driven processes such as laboratory evolution or random mutagenesis. A promising middle-ground approach is semi-rational engineering, where genetic modification targets a...
Autores principales: | Teoh, Shao Thing, Putri, Sastia, Mukai, Yukio, Bamba, Takeshi, Fukusaki, Eiichiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570087/ https://www.ncbi.nlm.nih.gov/pubmed/26379776 http://dx.doi.org/10.1186/s13068-015-0330-z |
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