Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy

Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cel...

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Detalles Bibliográficos
Autores principales: Van Acker, Heleen H, Anguille, Sébastien, Van Tendeloo, Viggo F, Lion, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570126/
https://www.ncbi.nlm.nih.gov/pubmed/26405575
http://dx.doi.org/10.1080/2162402X.2015.1021538
Descripción
Sumario:Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists.

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