Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy

Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cel...

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Detalles Bibliográficos
Autores principales: Van Acker, Heleen H, Anguille, Sébastien, Van Tendeloo, Viggo F, Lion, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570126/
https://www.ncbi.nlm.nih.gov/pubmed/26405575
http://dx.doi.org/10.1080/2162402X.2015.1021538
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author Van Acker, Heleen H
Anguille, Sébastien
Van Tendeloo, Viggo F
Lion, Eva
author_facet Van Acker, Heleen H
Anguille, Sébastien
Van Tendeloo, Viggo F
Lion, Eva
author_sort Van Acker, Heleen H
collection PubMed
description Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists.
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spelling pubmed-45701262016-02-03 Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy Van Acker, Heleen H Anguille, Sébastien Van Tendeloo, Viggo F Lion, Eva Oncoimmunology Review Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists. Taylor & Francis 2015-04-01 /pmc/articles/PMC4570126/ /pubmed/26405575 http://dx.doi.org/10.1080/2162402X.2015.1021538 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Van Acker, Heleen H
Anguille, Sébastien
Van Tendeloo, Viggo F
Lion, Eva
Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title_full Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title_fullStr Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title_full_unstemmed Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title_short Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
title_sort empowering gamma delta t cells with antitumor immunity by dendritic cell-based immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570126/
https://www.ncbi.nlm.nih.gov/pubmed/26405575
http://dx.doi.org/10.1080/2162402X.2015.1021538
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