IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and p...

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Detalles Bibliográficos
Autores principales: Lunardi, Serena, Lim, Su Yin, Muschel, Ruth J, Brunner, Thomas B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570127/
https://www.ncbi.nlm.nih.gov/pubmed/26405599
http://dx.doi.org/10.1080/2162402X.2015.1027473
Descripción
Sumario:Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

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