IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and p...

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Detalles Bibliográficos
Autores principales: Lunardi, Serena, Lim, Su Yin, Muschel, Ruth J, Brunner, Thomas B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570127/
https://www.ncbi.nlm.nih.gov/pubmed/26405599
http://dx.doi.org/10.1080/2162402X.2015.1027473
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author Lunardi, Serena
Lim, Su Yin
Muschel, Ruth J
Brunner, Thomas B
author_facet Lunardi, Serena
Lim, Su Yin
Muschel, Ruth J
Brunner, Thomas B
author_sort Lunardi, Serena
collection PubMed
description Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
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spelling pubmed-45701272016-02-03 IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer Lunardi, Serena Lim, Su Yin Muschel, Ruth J Brunner, Thomas B Oncoimmunology Author's View Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10. Taylor & Francis 2015-04-02 /pmc/articles/PMC4570127/ /pubmed/26405599 http://dx.doi.org/10.1080/2162402X.2015.1027473 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Lunardi, Serena
Lim, Su Yin
Muschel, Ruth J
Brunner, Thomas B
IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title_full IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title_fullStr IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title_full_unstemmed IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title_short IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
title_sort ip-10/cxcl10 attracts regulatory t cells: implication for pancreatic cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570127/
https://www.ncbi.nlm.nih.gov/pubmed/26405599
http://dx.doi.org/10.1080/2162402X.2015.1027473
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