Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumo...

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Detalles Bibliográficos
Autores principales: Rekers, Nicolle H, Zegers, Catharina ML, Germeraad, Wilfred TV, Dubois, Ludwig, Lambin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570128/
https://www.ncbi.nlm.nih.gov/pubmed/26405576
http://dx.doi.org/10.1080/2162402X.2015.1021541
Descripción
Sumario:Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

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