Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumo...

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Autores principales: Rekers, Nicolle H, Zegers, Catharina ML, Germeraad, Wilfred TV, Dubois, Ludwig, Lambin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570128/
https://www.ncbi.nlm.nih.gov/pubmed/26405576
http://dx.doi.org/10.1080/2162402X.2015.1021541
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author Rekers, Nicolle H
Zegers, Catharina ML
Germeraad, Wilfred TV
Dubois, Ludwig
Lambin, Philippe
author_facet Rekers, Nicolle H
Zegers, Catharina ML
Germeraad, Wilfred TV
Dubois, Ludwig
Lambin, Philippe
author_sort Rekers, Nicolle H
collection PubMed
description Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.
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spelling pubmed-45701282016-02-03 Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2 Rekers, Nicolle H Zegers, Catharina ML Germeraad, Wilfred TV Dubois, Ludwig Lambin, Philippe Oncoimmunology Author's View Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc. Taylor & Francis 2015-04-02 /pmc/articles/PMC4570128/ /pubmed/26405576 http://dx.doi.org/10.1080/2162402X.2015.1021541 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Rekers, Nicolle H
Zegers, Catharina ML
Germeraad, Wilfred TV
Dubois, Ludwig
Lambin, Philippe
Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title_full Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title_fullStr Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title_full_unstemmed Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title_short Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
title_sort long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine l19-il2
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570128/
https://www.ncbi.nlm.nih.gov/pubmed/26405576
http://dx.doi.org/10.1080/2162402X.2015.1021541
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