AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo

Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified...

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Detalles Bibliográficos
Autores principales: Wang, Xiaowen, Li, Kai, Liu, Ling, Shi, Qiong, Song, Pu, Jian, Zhe, Guo, Sen, Wang, Gang, Li, Chunying, Gao, Tianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570213/
https://www.ncbi.nlm.nih.gov/pubmed/26370050
http://dx.doi.org/10.1038/srep13542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570213/
https://www.ncbi.nlm.nih.gov/pubmed/26370050
http://dx.doi.org/10.1038/srep13542

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