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AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo
Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified...
Autores principales: | Wang, Xiaowen, Li, Kai, Liu, Ling, Shi, Qiong, Song, Pu, Jian, Zhe, Guo, Sen, Wang, Gang, Li, Chunying, Gao, Tianwen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570213/ https://www.ncbi.nlm.nih.gov/pubmed/26370050 http://dx.doi.org/10.1038/srep13542 |
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