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Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease
BACKGROUND: Transforming growth factor-beta (TGF-β) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety of cellular processes. In addition, several recent studies...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570595/ https://www.ncbi.nlm.nih.gov/pubmed/26484028 http://dx.doi.org/10.1016/j.krcp.2015.05.002 |
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author | Ki, Hye-Jin Kim, Se Yun Lee, Sang Ho Moon, Ju-Young Jeong, Kyung Hwan Lee, Tae Won Ihm, Chun Gyoo Kim, Su Kang Chung, Joo-Ho Kang, Sun Woo Kim, Tae Hee Kim, Yeong-Hoon Kim, Yang Gyun |
author_facet | Ki, Hye-Jin Kim, Se Yun Lee, Sang Ho Moon, Ju-Young Jeong, Kyung Hwan Lee, Tae Won Ihm, Chun Gyoo Kim, Su Kang Chung, Joo-Ho Kang, Sun Woo Kim, Tae Hee Kim, Yeong-Hoon Kim, Yang Gyun |
author_sort | Ki, Hye-Jin |
collection | PubMed |
description | BACKGROUND: Transforming growth factor-beta (TGF-β) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety of cellular processes. In addition, several recent studies have reported that TGF-β receptor (TGF-βR) gene polymorphism is associated with chronic kidney disease. However, the association between end-stage renal disease (ESRD) and the TGF-β gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the TGF-β ligands or their receptors may be related to ESRD. METHODS: We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the TGF-βR2 and TGF-β2 genes and ESRD, in 312 patients with ESRD and 258 controls. RESULTS: Compared with the control participants, the frequencies of the TGF-βR2 (rs764522(⁎)C) and TGF-βR2 (rs3087465(⁎)G) alleles were significantly higher in the patients with ESRD. Genotyping analysis demonstrated that two SNPs in TGF-βR2 of the four SNPs included in the study were significantly associated with ESRD in the codominant 1 [rs764522, odds ratio (OR)=1.65; rs3087465, OR=1.63], dominant (rs764522, OR=1.63; rs3087465, OR=1.57), and log-additive (rs764522, OR=1.54; rs3087465, OR=1.39) models after adjusting for age and sex. CONCLUSION: We suggest that TGF-βR2 polymorphisms (rs764522 and rs3087465) increase the risk of development of ESRD. |
format | Online Article Text |
id | pubmed-4570595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45705952015-10-19 Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease Ki, Hye-Jin Kim, Se Yun Lee, Sang Ho Moon, Ju-Young Jeong, Kyung Hwan Lee, Tae Won Ihm, Chun Gyoo Kim, Su Kang Chung, Joo-Ho Kang, Sun Woo Kim, Tae Hee Kim, Yeong-Hoon Kim, Yang Gyun Kidney Res Clin Pract Original Article BACKGROUND: Transforming growth factor-beta (TGF-β) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety of cellular processes. In addition, several recent studies have reported that TGF-β receptor (TGF-βR) gene polymorphism is associated with chronic kidney disease. However, the association between end-stage renal disease (ESRD) and the TGF-β gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the TGF-β ligands or their receptors may be related to ESRD. METHODS: We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the TGF-βR2 and TGF-β2 genes and ESRD, in 312 patients with ESRD and 258 controls. RESULTS: Compared with the control participants, the frequencies of the TGF-βR2 (rs764522(⁎)C) and TGF-βR2 (rs3087465(⁎)G) alleles were significantly higher in the patients with ESRD. Genotyping analysis demonstrated that two SNPs in TGF-βR2 of the four SNPs included in the study were significantly associated with ESRD in the codominant 1 [rs764522, odds ratio (OR)=1.65; rs3087465, OR=1.63], dominant (rs764522, OR=1.63; rs3087465, OR=1.57), and log-additive (rs764522, OR=1.54; rs3087465, OR=1.39) models after adjusting for age and sex. CONCLUSION: We suggest that TGF-βR2 polymorphisms (rs764522 and rs3087465) increase the risk of development of ESRD. Elsevier 2015-06 2015-05-29 /pmc/articles/PMC4570595/ /pubmed/26484028 http://dx.doi.org/10.1016/j.krcp.2015.05.002 Text en Copyright © 2015. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Ki, Hye-Jin Kim, Se Yun Lee, Sang Ho Moon, Ju-Young Jeong, Kyung Hwan Lee, Tae Won Ihm, Chun Gyoo Kim, Su Kang Chung, Joo-Ho Kang, Sun Woo Kim, Tae Hee Kim, Yeong-Hoon Kim, Yang Gyun Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title | Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title_full | Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title_fullStr | Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title_full_unstemmed | Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title_short | Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
title_sort | transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570595/ https://www.ncbi.nlm.nih.gov/pubmed/26484028 http://dx.doi.org/10.1016/j.krcp.2015.05.002 |
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