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Does hypokalemia contribute to acute kidney injury in chronic laxative abuse?
Prolonged hypokalemia from chronic laxative abuse is recognized as the cause of chronic tubulointerstitial disease, known as “hypokalemic nephropathy,” but it is not clear whether it contributes to acute kidney injury (AKI). A 42-year-old woman with a history of chronic kidney disease as a result of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570648/ https://www.ncbi.nlm.nih.gov/pubmed/26484031 http://dx.doi.org/10.1016/j.krcp.2014.10.009 |
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author | Lee, Eun-Young Yoon, Hyaejin Yi, Joo-Hark Jung, Woon-Yong Han, Sang-Woong Kim, Ho-Jung |
author_facet | Lee, Eun-Young Yoon, Hyaejin Yi, Joo-Hark Jung, Woon-Yong Han, Sang-Woong Kim, Ho-Jung |
author_sort | Lee, Eun-Young |
collection | PubMed |
description | Prolonged hypokalemia from chronic laxative abuse is recognized as the cause of chronic tubulointerstitial disease, known as “hypokalemic nephropathy,” but it is not clear whether it contributes to acute kidney injury (AKI). A 42-year-old woman with a history of chronic kidney disease as a result of chronic laxative abuse from a purging type of anorexia nervosa (AN-P), developed an anuric AKI requiring hemodialysis and a mild AKI 2 months later. Both episodes of AKI involved severe to moderate hypokalemia (1.2 and 2.7 mmol/L, respectively), volume depletion, and mild rhabdomyolysis. The histologic findings of the first AKI revealed the remnants of acute tubular necrosis with advanced chronic tubulointerstitial nephritis and ischemic glomerular injury. Along with these observations, the intertwined relationship among precipitants of recurrent AKI in AN-P is discussed, and then we postulate a contributory role of hypokalemia involved in the pathophysiology of the renal ischemia-induced AKI. |
format | Online Article Text |
id | pubmed-4570648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45706482015-10-19 Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? Lee, Eun-Young Yoon, Hyaejin Yi, Joo-Hark Jung, Woon-Yong Han, Sang-Woong Kim, Ho-Jung Kidney Res Clin Pract Case Report Prolonged hypokalemia from chronic laxative abuse is recognized as the cause of chronic tubulointerstitial disease, known as “hypokalemic nephropathy,” but it is not clear whether it contributes to acute kidney injury (AKI). A 42-year-old woman with a history of chronic kidney disease as a result of chronic laxative abuse from a purging type of anorexia nervosa (AN-P), developed an anuric AKI requiring hemodialysis and a mild AKI 2 months later. Both episodes of AKI involved severe to moderate hypokalemia (1.2 and 2.7 mmol/L, respectively), volume depletion, and mild rhabdomyolysis. The histologic findings of the first AKI revealed the remnants of acute tubular necrosis with advanced chronic tubulointerstitial nephritis and ischemic glomerular injury. Along with these observations, the intertwined relationship among precipitants of recurrent AKI in AN-P is discussed, and then we postulate a contributory role of hypokalemia involved in the pathophysiology of the renal ischemia-induced AKI. Elsevier 2015-06 2015-03-27 /pmc/articles/PMC4570648/ /pubmed/26484031 http://dx.doi.org/10.1016/j.krcp.2014.10.009 Text en Copyright © 2015. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Lee, Eun-Young Yoon, Hyaejin Yi, Joo-Hark Jung, Woon-Yong Han, Sang-Woong Kim, Ho-Jung Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title | Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title_full | Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title_fullStr | Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title_full_unstemmed | Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title_short | Does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
title_sort | does hypokalemia contribute to acute kidney injury in chronic laxative abuse? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570648/ https://www.ncbi.nlm.nih.gov/pubmed/26484031 http://dx.doi.org/10.1016/j.krcp.2014.10.009 |
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