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Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma

BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has been rising in recent years. Given the clinical impact of HPV/p16 positivity in OPSCC, identifying surrogate markers of this disease early in the diagnostic work-up of these patients cou...

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Autores principales: Clark, Jessica, Jeffery, Caroline C., Zhang, Han, Cooper, Tim, O’Connell, Daniel A., Harris, Jeffrey, Seikaly, Hadi, Biron, Vincent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570692/
https://www.ncbi.nlm.nih.gov/pubmed/26374294
http://dx.doi.org/10.1186/s40463-015-0091-5
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author Clark, Jessica
Jeffery, Caroline C.
Zhang, Han
Cooper, Tim
O’Connell, Daniel A.
Harris, Jeffrey
Seikaly, Hadi
Biron, Vincent L.
author_facet Clark, Jessica
Jeffery, Caroline C.
Zhang, Han
Cooper, Tim
O’Connell, Daniel A.
Harris, Jeffrey
Seikaly, Hadi
Biron, Vincent L.
author_sort Clark, Jessica
collection PubMed
description BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has been rising in recent years. Given the clinical impact of HPV/p16 positivity in OPSCC, identifying surrogate markers of this disease early in the diagnostic work-up of these patients could improve patient care. METHODS: Demographic, pathologic, staging and PET-CT data from patients diagnosed with OPSCC from 2009–2014 were obtained from a prospectively collected provincial cancer registry. Tumor HPV/p16 status was correlated to the maximum standard uptake value (SUVmax) of the primary tumor and cervical nodes. Comparisons of means and multinomial regression models were used to determine associations between p16 status and SUVmax. A diagnostic odds ratio was calculated using a cut off value for predicting HPV/p16 positivity based on nodal SUVmax. RESULTS: PET-CT and HPV/p16 data was obtained for 65 patients treated surgically for OPSCC. Significantly higher nodal SUVmax was associated with HPV/p16 positive nodes (SUVmax 10.8 vs 7.9). No significant differences were seen between HPV/p16 positive vs negative primary tumor SUVmax (10.3 vs 13.7). In combination with other clinical parameters, higher nodal SUVmax was highly correlated with HPV/p16 positivity. CONCLUSION: Elevated nodal SUVmax is a significant predictor of HPV/p16 positive disease.
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spelling pubmed-45706922015-09-16 Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma Clark, Jessica Jeffery, Caroline C. Zhang, Han Cooper, Tim O’Connell, Daniel A. Harris, Jeffrey Seikaly, Hadi Biron, Vincent L. J Otolaryngol Head Neck Surg Original Research Article BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has been rising in recent years. Given the clinical impact of HPV/p16 positivity in OPSCC, identifying surrogate markers of this disease early in the diagnostic work-up of these patients could improve patient care. METHODS: Demographic, pathologic, staging and PET-CT data from patients diagnosed with OPSCC from 2009–2014 were obtained from a prospectively collected provincial cancer registry. Tumor HPV/p16 status was correlated to the maximum standard uptake value (SUVmax) of the primary tumor and cervical nodes. Comparisons of means and multinomial regression models were used to determine associations between p16 status and SUVmax. A diagnostic odds ratio was calculated using a cut off value for predicting HPV/p16 positivity based on nodal SUVmax. RESULTS: PET-CT and HPV/p16 data was obtained for 65 patients treated surgically for OPSCC. Significantly higher nodal SUVmax was associated with HPV/p16 positive nodes (SUVmax 10.8 vs 7.9). No significant differences were seen between HPV/p16 positive vs negative primary tumor SUVmax (10.3 vs 13.7). In combination with other clinical parameters, higher nodal SUVmax was highly correlated with HPV/p16 positivity. CONCLUSION: Elevated nodal SUVmax is a significant predictor of HPV/p16 positive disease. BioMed Central 2015-09-15 /pmc/articles/PMC4570692/ /pubmed/26374294 http://dx.doi.org/10.1186/s40463-015-0091-5 Text en © Clark et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Research Article
Clark, Jessica
Jeffery, Caroline C.
Zhang, Han
Cooper, Tim
O’Connell, Daniel A.
Harris, Jeffrey
Seikaly, Hadi
Biron, Vincent L.
Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title_full Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title_fullStr Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title_full_unstemmed Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title_short Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma
title_sort correlation of pet-ct nodal suvmax with p16 positivity in oropharyngeal squamous cell carcinoma
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570692/
https://www.ncbi.nlm.nih.gov/pubmed/26374294
http://dx.doi.org/10.1186/s40463-015-0091-5
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